Project Leads: Robert Moritz, Jeff Ranish
The quantitative, sensitive and comprehensive measurement of proteins and their interactions remains a significant challenge for proteomics. Yet such measurements are critical to developing predictive models of protein-based network structures, and the dynamics that underlie biological responses. The research projects drive the development of: 1) comprehensive quantitative measurements of proteomes and sub proteomes, lipidomes, metabolomes, post-translational modifications, protein/protein or nucleic acid/protein interactions and their dynamics, and 2) metrics for the quality of proteomics measurements including protein identification, quantification, interactions, and modifications.
The Proteomics core facility provides informatics and user support, maintains key instrumentation, and develops new assays such as single-cell copy-number-variation assays.