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Model Systems

Halobacterium
Yeast Peroxisome Biogenesis
Yeast Cell Differentiation

Mammalian Systems

Disease Diagnostics
Innate Immunity

Computational Biology Research

Computational Biology
Research and Scientists

Model Systems


 Halobacterium
Nitin Baliga is characterizing regulatory networks in Halobacterium salinarum using complementary systems approaches – e.g. physically mapping interactions and statistically learning functional associations from systems biology data.… More


 Yeast Peroxisome Biogenesis
John Aitchison is conducting research to gain systems-level insight into the regulatory networks governing peroxisome induction. To understand peroxisome dynamics and function, the signaling control that precedes the molecular events of peroxisomal compartment expansion must be understood. More


 Yeast Cell Differentiation
Tim Galitski is seeking to understand biological information transmission from signaling circuits to transcriptional regulation paths that control filamentous-form cell differentiation. More

Mammalian Systems


 Disease Diagnostics
Leroy Hood is developing the technical and computational tools for blood diagnostics, using glioblastoma multiforme and other organ perturbations (disease and environmental) as models. More

 Innate Immunity
Adrian Ozinsky is developing single cell analysis tools to define the structure and regulation of the Toll-like Receptor (TLR) signaling pathway that mediates defense responses in innate immune cells during infections. These single cell tools also are being used to purify and study human breast cancer stem cells. More

Computational Biology Research


 Computational Biology
Ilya Shmulevich's Computational Biology Research group; i) works with diverse data types to construct models of biomolecular systems; ii) develops and uses theories of complex systems to gain fundamental insights into the organization, information processing, and dynamics of living systems; iii) develops machine learning methods for biomarker discovery, particularly in the context of cancer, and iv) develops image analysis approaches for high-throughput cellular imaging and microfluidic platforms. More


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